• 人工智能开启中国健康养殖新时代 “智慧农业——健康养殖公益行动”在北京正式启动 2019-10-08
  • 张一山恋情疑曝光 网友的细心程度令人佩服 2019-10-06
  • 人民网2017呼和浩特徒步迎新活动--内蒙古频道--人民网 2019-10-06
  • 农民特别保守,将自己土体的主人,变成国家的佃户,非常保守 2019-09-20
  • 5月份全国财政收入稳步增长 支出结构不断优化 2019-09-20
  • 交通运输业、除去货运、客运也都是人满为患吃大锅饭的状态。裁员也会是惊人的。所以中国劳动力不是太少、而是都不仅在位置上。国有企事业单位冗员严重。数量惊人。 2019-09-18
  • 湖北城镇公厕建设技术导则出台 每平方公里应有3到5座公厕 2019-09-14
  • 人民日报看山西--山西频道--人民网 2019-09-02
  • 感触名家笔下的端午文化 吃香粽原来可以这样"文艺" 2019-09-02
  • 最便宜的进口越野型SUV,全新一代车型曝光,预计15万不到! 2019-08-27
  • 习近平教我们认识和把握世界大势和时代潮流 2019-08-25
  • 官宣!女排四大功勋球员同时退役 没有两大前国手 2019-08-25
  • 大象堵路男子下车拍照 被踩踏致死 2019-08-03
  • 【新时代·幸福美丽新边疆】镜像海南 2019-07-26
  • 规范二手交易平台须多方给力 2019-07-26
  •  
     
    name

    帕尔马香水男士:Rosemary Extract Carnosic acid

    发布时间 2018-05-29
    Clicks 498
    Product name: Rosemary Extract Carnosic acid
    上市date: 2018-05-29
    Product Details

    帕尔马玫瑰香味 www.yswi.net Name : Rosemary Extract Carnosic acid

    Source: Rosemary ?

    Botanical Name : Rosmarinus officinalis

    Extract part: Leaf?

    Composition : Carnosic acid

    Purity:60%

    Appearance: Fine Brownish Yellow powder

    Country of origin:P.R. China

    ?

    Source

    Rosmarinus officinalis L. from Lamiaceae family, is commonly known as rosemary.?Rosemary is a widely cultivated herbal plant that is originated in the Mediterranean area. Rosemary is an aromatic evergreen shrub with leaves similar to?hemlock?needles .The leaves are used as a flavoring in foods and a prescription for treating minor ailments including :gout, cough, headache, high blood pressure, and reducing age-related memory loss.

    Rosemary is used topically for preventing and treating baldness by applying to the skin ; and treating circulation problems, toothache, a skin condition called eczema, and joint or muscle pain such as myalgia, sciatica, and intercostal neuralgia. It is also used for wound healing, in bath therapy (balneotherapy), and as an insect repellent.

    ?

    Main Bio-actives

    Rosemary contains a number of phytochemicals, including rosmarinic acid, camphor, caffeic acid, ursolic acid, betulinic acid, rosmanol and the antioxidants carnosic acid and carnosol.

    Rosmarinic acid is a chemical compound firstly found in Rosmarinus officinalis which has antioxidant properties.

    Another main antioxidant in rosemary is the phenolic diterpene carnosic acid ,appears to be the main substance for general oxidation leading to artifacts withγ-or δ-lactone structure in extracts of Rosmarinus officinalis .

    Rosmarinic acid is a caffeic acid ester of salvianic acid A that acts as a GABA transaminase inhibitor, more specifically on 4-aminobutyrate transaminase.Rosmarinic acid also inhibits the expression of indoleamine 2,3-dioxygenase via its cyclooxygenase-inhibiting properties.

    ?

    Functions

    Antioxidant

    Constituents in Rosemary extracts from Rosmarinus officinalis L contains several compounds proven to have antioxidative function.Early investigation proved that carnosol and carnosic acid have been suggested to account for over 90% of the antioxidant properties of rosemary extract.Purified carnosol and carnosic acid are powerful inhibitors of lipid peroxidation in microsomal and liposomal systems, more effective than propyl gallate.Carnosol and carnosic acid are good scavengers of peroxyl radicals (CCl3O2) generated by pulse radiolysis, with calculated rate constants of 1–3 × 106M-1?S-1?and 2.7 × 107M-1?S-1?respectively.Carnosic acid reacted with HOCl in such a way as to protect the protein α1-antiproteinase against inactivationand appears to scavenge H2O2, but it could also act as a substrate for the peroxidase system.Both carnosol and carnosic acid stimulated DNA damage in the bleomycin assay but they scavenged hydroxyl radicals in the deoxyribose assay. The calculated rate constants for reaction with ·OH in the deoxyribose system for carnosol and carnosic acid were 8.7 × 1010M-1?and 5.9 × 1010M-1?S-1respectively.Moreover they also reduce cytochrome c but with a rate constant significantly lower than that of O-.2.

    ?

    Anti-inflammatory

    Biosci Biotechnol Biochem.?reported in 2007 supercritical fluid SF-CO2 treatment of Rosemarinus officinalis L. fresh leaves under optimum conditions (80 degrees C at 5,000 psi) yielded 5.3% of extract supercritical fluid extraction (SFE)-80, in which five major active principles were identified by liquid chromatography/mass spectrometry (LC/MS), viz., rosmarinic acid, carnosol, 12-methoxycarnosic acid, carnosic acid, and methyl carnosate.

    When treated in RAW 264.7, apparent dose-dependent NO inhibition. SFE-80 exhibited dose-dependent viability suppression and significant tumor necrosis factor alpha (TNF-alpha) production in Hep 3B, whereas no effect was found in Chang liver cells. Furthermore, no effect was observed in RAW 264.7 at dosages of 3.13 to 25 microg/ml, indicating that SFE-80 exhibited a noncytotoxic character. Conclusively, rosemary can be considered an herbal anti-inflammatory and anti-tumor agent.

    ?

    Anticancer

    Carnosic acid, a phenolic diterpene, exhibited potent antioxidant and anticancer properties in both in vivo and in vitro conditions?.Recent research examined whether carnosic acid could sensitize TRAIL-mediated apoptosis in human renal carcinoma Caki cells.Research found that carnosic acid markedly induced TRAIL-mediated apoptosis in human renal carcinoma (Caki, ACHN, and A498), and human hepatocellular carcinoma (SK-HEP-1), and human breast carcinoma (MDA-MB-231) cells, but not normal cells (TMCK-1 and HSF). Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization. Furthermore, carnosic acid induced death receptor (DR)5, Bcl-2 interacting mediator of cell death (Bim), and p53 up-regulated modulator of apoptosis (PUMA) expression at the transcriptional levels via CCAAT/enhancer-binding protein-homologous protein (CHOP). Down-regulation of CHOP expression by siRNA inhibited DR5, Bim, and PUMA expression, and attenuated carnosic acid plus TRAIL-induced apoptosis.In conclusion,study demonstrates that carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression, and up-regulation of ER stress-mediated DR5, Bim, and PUMA expression at the transcriptional levels.

    ?

    Antiviral activity

    Study on Human respiratory syncytial virus (hRSV) revealed the bioactive ?constituent of an extract of?Rosmarinus officinalis,carnosic acid , exerted a strong inhibitory effect against hRSV infection.

    Among the tested bioactive constituents of?R. officinalis, carnosic acid displayed the most potent anti-hRSV activity and was effective against both A- and B-type viruses. Carnosic acid efficiently suppressed the replication of hRSV in a concentration-dependent manner. Carnosic acid effectively suppressed viral gene expression without inducing type-I interferon production or affecting cell viability, suggesting that it may directly affect viral factors. A time course analysis showed that addition of carnosic acid 8 hours after infection still effectively blocked the expression of hRSV genes, further suggesting that carnosic acid directly inhibited the replication of hRSV.

    ?

    Neuroprotective

    The importance of free radical-induced oxidative damage after traumatic brain injury (TBI) has been well documented. Despite multiple clinical trials with radical-scavenging antioxidants that are neuroprotective in TBI models, none is approved for acute TBI patients. As an alternative antioxidant target, Nrf2 is a transcription factor that activates expression of antioxidant and cytoprotective genes by binding to antioxidant response elements (ARE) within DNA.Researchers hypothesized that administration of carnosic acid (CA) would reduce oxidative damage biomarkers in brain tissue and also preserve cortical mitochondrial respiratory function post-TBI. A mouse controlled cortical impact (CCI) model was employed with a 1.0mm cortical deformation injury. Administration of CA at 15 minutes post-TBI reduced cortical lipid peroxidation, protein nitration, and cytoskeletal breakdown markers in a dose-dependent manner at 48 hours post-injury. Moreover, CA preserved mitochondrial respiratory function compared to vehicle animals. This was accompanied by decreased oxidative damage to mitochondrial proteins, suggesting the mechanistic connection of the two effects. Lastly, delaying the initial administration of CA up to 8 hours post-TBI was still capable of reducing cytoskeletal breakdown, thereby demonstrating a clinically relevant therapeutic window for this approach. This study demonstrates that pharmacological Nrf2-ARE induction is capable of neuroprotective efficacy when administered after TBI.

    ?

    Applications

    Carnosic acid is known to has multiple potent biochemical activities including antioxidant,antiviral ,anticancer and anti-inflammatory.Researches suggested that Carnosic acid has potential application in medical treatment .


  • If you have any questions, suggestions, please leave a message, we will promptly give you feedback!
    • Name
    • *
    • Company name:
    • *
    • Address:
    • *
    • Phone
    • *
    • Fax:
    • *
    • Mailbox
    • *
    • Zip code:
    • *
    • Message Subject:
    • *
    • Content
    • *
    Hot Products / Hot deals More
    2017 - 10 - 13
    Polygonum Cuspidatum ExtractLatin Name: Polygonum CuspidatumActive Ingredient: resveratrolCAS No.: 501-36-0Test method: HPLCSpecifications: 50%98%Product Description:Basic inforName : Reynoutria japonica Houtt extract Other name: Polygonum cuspidatum Source:Polygonum cuspidatum root Latin name:Reynoutria japonica HouttIngredient: ResveratrolSpecfication : 50...
    2018 - 05 - 29
    Name : Rosemary Extract Carnosic acidSource: Rosemary  Botanical Name : Rosmarinus officinalisExtract part: Leaf Composition : Carnosic acidPurity:60%Appearance: Fine Brownish Yellow powderCountry of origin:P.R. China SourceRosmarinus officinalis L. from Lamiaceae family, is commonly known as rosemary. Rosemary is a widely cultivated herbal plant that is originated in the Medit...
    2017 - 10 - 13
    Cacao husk pigmentName :Cocoa Extract PigmentSource: CocoaBotanical Name :Theobroma cacaoExtract part: Bean shellAssay:Color Value (EL%1cm535±5nm)NLT50Identification measure :UV-VISAppearance: Fine Brown powder Country of origin:P.R. China SourceCacao  is usually refereed to the dried and fully fermented fatty seed of Theobroma cacao ,the plant from which ch...
    2017 - 10 - 13
    Basic infor Name : Horny Goat Weed Extract Other name:Epimedium davidii Franch   Source:EpimediumdavidiiFranch  leaf Latin name: EpimediumdavidiiFranch  Ingredient: Icariin Specfication :5%-98% Icariin、10:1  Test methods:HP676.66LC/TLCCAS No.: 489-32-7Molecular Formula:C33H40O15 Molecular ...
    Contact Us:
    Phone: 86 731-82739228
    Company Address: A301, 1st building, 188# Huanbao Rd.,Changsha 410016, P.R. China
    网站备案: 湘ICP备17017657号   
    Copyright ?2005 - 2017 Organic Herb Inc
    犀牛云提供企业云服务
    Links
  • 人工智能开启中国健康养殖新时代 “智慧农业——健康养殖公益行动”在北京正式启动 2019-10-08
  • 张一山恋情疑曝光 网友的细心程度令人佩服 2019-10-06
  • 人民网2017呼和浩特徒步迎新活动--内蒙古频道--人民网 2019-10-06
  • 农民特别保守,将自己土体的主人,变成国家的佃户,非常保守 2019-09-20
  • 5月份全国财政收入稳步增长 支出结构不断优化 2019-09-20
  • 交通运输业、除去货运、客运也都是人满为患吃大锅饭的状态。裁员也会是惊人的。所以中国劳动力不是太少、而是都不仅在位置上。国有企事业单位冗员严重。数量惊人。 2019-09-18
  • 湖北城镇公厕建设技术导则出台 每平方公里应有3到5座公厕 2019-09-14
  • 人民日报看山西--山西频道--人民网 2019-09-02
  • 感触名家笔下的端午文化 吃香粽原来可以这样"文艺" 2019-09-02
  • 最便宜的进口越野型SUV,全新一代车型曝光,预计15万不到! 2019-08-27
  • 习近平教我们认识和把握世界大势和时代潮流 2019-08-25
  • 官宣!女排四大功勋球员同时退役 没有两大前国手 2019-08-25
  • 大象堵路男子下车拍照 被踩踏致死 2019-08-03
  • 【新时代·幸福美丽新边疆】镜像海南 2019-07-26
  • 规范二手交易平台须多方给力 2019-07-26
  • 意大利pk10软件怎么玩 三公棋牌游戏 通比牛牛下载 看四张牌抢庄牛牛技巧 重庆时时彩APP苹果版 千里马计划app怎么下载 重庆时时彩2.1版本安卓 pk10走势图分析 澳洲时时彩是私彩吗 幸运28天涯论坛 恒发彩票链接 历史开奖手机完整版 不限ip多账号送彩金 时时彩万位6码100% 菠菜计划软件 大小单双稳赚技巧